107922-02-1

Basic information

• Product Name: 1-(3-methyl-6-phenylimidazo[2,1-b][1,3]thiazol-2-yl)ethanone
• Synonyms: 1-(3-methyl-6-phenylimidazo[2,1-b][1,3]thiazol-2-yl)ethanone
• CAS NO: 107922-02-1
• Molecular Weight: 256.328
• Mol File: 107922-02-1.mol

Chemical Properties

• CAS DataBase Reference: 1-(3-methyl-6-phenylimidazo[2,1-b][1,3]thiazol-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-methyl-6-phenylimidazo[2,1-b][1,3]thiazol-2-yl)ethanone(107922-02-1)
• EPA Substance Registry System: 1-(3-methyl-6-phenylimidazo[2,1-b][1,3]thiazol-2-yl)ethanone(107922-02-1)

Safety Data

• Hazardous Substances Data: 107922-02-1(Hazardous Substances Data)

Usage

Molecular structure

The compound consists of a thiazole ring fused to an imidazole ring, with a methyl group and a phenyl group attached.

Functional groups

It contains an ethanone functional group, which is a ketone attached to an ethyl group.

Potential applications

It may have potential uses in pharmaceuticals, agrochemicals, or materials science.

Biological or chemical properties

Its unique structure and functional groups give it the potential to exhibit specific biological or chemical properties.

Research and development

The compound is of interest for further research and development due to its potential applications and properties.

Solubility

The solubility of this compound in various solvents is not mentioned in the provided material, but it may vary depending on the polarity of the solvent.

Stability

The stability of the compound under different conditions (e.g., temperature, pH, light exposure) is not provided in the material, but it could be an important factor to consider for its potential applications.

Synthesis

The method of synthesis for this compound is not provided in the material, but it could involve the formation of the thiazole-imidazole fused ring system and subsequent functionalization with the methyl and phenyl groups, followed by the introduction of the ethanone group.

Analytical techniques

Various analytical techniques, such as nuclear magnetic resonance (NMR), mass spectrometry (MS), and infrared (IR) spectroscopy, can be used to characterize and confirm the structure of this compound.

Upstream product

• 109508-79-4 3-(4-phenyl-1⁽³⁾H-imidazol-2-ylmercapto)-pentane-2,4-dione 
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• 6857-34-7 2-mercapto-4⁽⁵⁾-phenylimidazole 
• 6857-34-7 4-phenyl-1,3-dihydro-2H-imidazole-2-thione 
• 1694-29-7 3-chloropentane-2,4-dione 

Downstream Products

• 436850-19-0 1-(3-methyl-(4H)-5-phenylimidazo[2,1-b]thiazol-2-yl)ethylidenemalononitrile 
• 436850-02-1 3-oxo-2-phenylphydrazono-3-[3-methyl-(4H)-5-phenylimidazo[2,1-b]thiazol-2-yl]propanal 
• 436850-13-4 ethyl 2-oxo-5-phenylazo-6-[3-methyl-(4H)-5-phenylimidazo[2,1-b]thiazol-2-yl]-4H-pyrane-3-carboxylate 

Relevant articles and documents

Microwave-assisted green synthesis of new imidazo[2,1-b]thiazole derivatives and their antimicrobial, antimalarial, and antitubercular activities

Abstract: We have synthesized some imidazo[2,1-b]thiazole derivatives by reaction of 1-(2-amino-4-methylthiazol-5-yl)ethanone or ethyl 2-amino-4-methylthiazole-5-carboxylate with α-bromo aralkyl ketones (phenacyl bromides) in presence of polyethylene glycol-400 (PEG-400) as efficient, inexpensive, biodegradable, and green reaction medium and catalyst (dual nature) under Microwave Irradiation (MWI) at 300?W as well as under thermal heating at 90?°C. Moreover, we also synthesized 1-(2-amino-4-methylthiazol-5-yl)ethanone and ethyl 2-amino-4-methylthiazole-5-carboxylate by one-pot reaction of acetyl acetone/ethyl acetoacetate with N-bromosuccinimide (NBS) and thiourea in presence of PEG-400 under microwave irradiation at 180?W. All synthesized compounds were screened for antimicrobial and antimalarial activities. All compounds were found to show good to excellent antibacterial activity, and some analogs exhibited good antimalarial activity.

Features of the reaction of unsymmetrical 2-mercapto-imidazoles with aromatic and aliphatic ketones

The cyclization of unsymmetrical 2-mercaptoimidazoles with aliphatic and aromatic ketones has been studied. Using 1H NMR and X-ray analysis it has been shown that 4-R1-1H-2-mercaptoimidazoles undergo selective oxidative cyclization t

Synthesis of new pyridazin-6-ones, pyridazin-6-imines, 4-pyridazinals, and pyridines

3-Dimethyl-1-[3-methyl-(4H)-5-phenylimidazol[2,1-b]thiazol-2-yl]prop-2-enone 4 couples smoothly with benzenediazonium chloride to yield propanal 5 which is a key intermediate for the synthesis of pyridazinones 9-13, 16 and pyridazine-6-imine 8, 19. Pentadienonitrile 18 was converted into pyridine-3-carbonitrile 20 on refluxing in ethanolic sodium ethoxide solution. Pyrazole 24 was synthesized from the reaction of 5 with 1-chloro-2-phenylhydrazono propan-2-one 22.