1079267-22-3Relevant academic research and scientific papers
CYP19 (aromatase): Exploring the scaffold flexibility for novel selective inhibitors
Castellano, Sabrina,Stefancich, Giorgio,Ragno, Rino,Schewe, Katarzyna,Santoriello, Marisabella,Caroli, Antonia,Hartmann, Rolf W.,Sbardella, Gianluca
, p. 8349 - 8358 (2008)
Several derivatives out of a series of antifungal agents exhibited a good inhibitory potency against aromatase as well as a fairly good selectivity toward CYP17, even if lacking H-bond accepting substituents. Their common structural feature is a flexible backbone that did not fit into previously reported CYP19 models. Thus, a ligand-based approach was exploited to develop a novel statistically robust, self-consistent and predictive 3D-QSAR model herein proposed as a helpful tool to design new aromatase inhibitors.
