107930-44-9Relevant academic research and scientific papers
Synthesis of taxoids II. Synthesis and antitumor activity of water-soluble taxoids
Harada, Naoyuki,Ozaki, Kunihiko,Yamaguchi, Tetsuo,Arakawa, Hiroaki,Ando, Akira,Oda, Kouji,Nakanishi, Noriyuki,Ohashi, Motoaki,Hashiyama, Tomiki,Tsujihara, Kenji
, p. 241 - 258 (2007/10/03)
Synthesis of novel taxoid water-soluble prodrugs that have 2′-substituted amino acid derivatives with spacer is described. Enantioselective synthesis of the C-13 side chains proceeded through the asymmetric dihydroxylation. Several compounds had good solubility in saline and showed potent antitumor activity against B16 melanoma in mice.
