1079340-01-4Relevant academic research and scientific papers
Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure
Gawin, Rafal,De Clercq, Erik,Naesens, Lieve,Koszytkowska-Stawinska, Mariola
experimental part, p. 8379 - 8389 (2009/04/11)
The acyclic azanucleosides with 2-, 3-, or 4-aminobenzenesulfonyl function at the nitrogen atom of the sugar mimic were prepared by coupling of 2-, 3-, or 4-nitro-N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)benzenesulfonamide with the silylated pyrimidine nucleobases followed by the reduction of the nitro group with sodium dithionite in aqueous solution or the palladium-catalysed transfer hydrogenation. The azanucleosides were evaluated for, but found to be devoid of, activity against several RNA- and DNA-viruses in vitro.
