1079357-00-8

Basic information

• Product Name: C₂₆H₂₅FN₆O₇
• CAS NO: 1079357-00-8
• Molecular Weight: 552.519
• Mol File: 1079357-00-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₅FN₆O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₅FN₆O₇(1079357-00-8)
• EPA Substance Registry System: C₂₆H₂₅FN₆O₇(1079357-00-8)

Safety Data

• Hazardous Substances Data: 1079357-00-8(Hazardous Substances Data)

Upstream product

• 6953-35-1 2-(5-nitro-1H-indol-3-yl)-2-oxoacetyl chloride 
• 154590-66-6 (S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 

Relevant articles and documents

Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents

Novel oxazolidinone antibacterials bearing a variety of 3-indolylglyoxamide substituents have been explored in an effort to improve the spectrum and potency of this class of agents. A subclass of this series was also made with the diversity at C-5 terminus. These derivatives have been screened against a panel of clinically relevant Gram-positive pathogens and fastidious Gram-negative organisms. Several analogs in this series were identified with in vitro activity superior to linezolid (MIC = 0.25-2 μg/mL). Compounds 10a, 10c, 10e and 10f displayed activity against linezolid resistant Gram-positive organisms (MIC = 2-4 μg/mL). Selected oxazolidinones were evaluated for in vivo efficacy against a mouse systemic infection model.