107939-19-5Relevant academic research and scientific papers
Engineering Cytochrome P450s for Enantioselective Cyclopropenation of Internal Alkynes
Chen, Kai,Arnold, Frances H.
, p. 6891 - 6895 (2020)
We report a biocatalytic platform of engineered cytochrome P450 enzymes to carry out efficient cyclopropene synthesis via carbene transfer to internal alkynes. Directed evolution of a serine-ligated P450 variant, P411-C10, yielded a lineage of engineered
Regio- and Diastereoselective Copper-Catalyzed Carbomagnesiation for the Synthesis of Penta- and Hexa-Substituted Cyclopropanes
Cohen, Yair,Augustin, André U.,Levy, Laura,Jones, Peter G.,Werz, Daniel B.,Marek, Ilan
, p. 11804 - 11808 (2021)
Despite the highly strained nature of cyclopropanes possessing three vicinal quaternary carbon stereocenters, the regio- and diastereoselective copper-catalyzed carbomagnesiation reaction of cyclopropenes provides an easy and efficient access to these novel persubstituted cyclopropyl cores with a complete regio- and diastereoselectivity.
11. Selectivity in Rhodium(II)-Catalyzed Rearrangements of Cycloprop-2-ene-1-carboxylates
Mueller, Paul,Graenicher, Christian
, p. 129 - 144 (2007/10/02)
The course of the thermocatalytic rearrangement of cycloprop-2-ene-1-carboxylates in the presence of dirhodium(II) tetrakis(perfluorobutyrate) (Rh2(pfb)4>) was investigated by varying the substituents of the cyclopropene ring.Product composition is markedly influenced by the number, nature, and position of the substituents, which determine the regio- and stereoselectivity of the cyclopropene-ring cleavage.A mechanism is proposed in which attack of the electrophilic RhII species is concerted with disrotatory ring opening of the incipient cyclopropyl cation and affords a metal-complexed vinylcarbene.The chemoselectivity of the latter is consistent with that of other carbenes generated in the presence of .
