1079394-23-2

Upstream product

• 936548-80-0 3,3,3-trifluoro-N-(4-mercaptophenyl)propanamide 
• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 1061682-23-2 N-(4-(4,6-dichloropyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide 

Downstream Products

• 1079394-15-2 N-(4-(4-(4H-1,2,4-triazol-3-ylamino)-6-(3-cyclopropyl-3-fluoroazetidin-1-yl)pyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide 

Relevant academic research and scientific papers

AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Ht is A,B,C,D,E wherein said Ht is optionally and independently substituted with R2 and R2', provided that Ht is not pyrazolyl or thiazolyl; X is CH, N, 0, or S; Y is CH, N, 0, or S; Q is -O-, -NR'-, -S-, -C(=O)-, or -C(R' )2-; Rx is H or F; Rγ is -Z-R10; R1 is T- (Ring D);

AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.