107945-66-4Relevant academic research and scientific papers
HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY
-
Paragraph 1182; 1183, (2015/11/16)
Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X, X, and Xare N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I foranddiagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
8-FLUOROPHTHALAZIN-1(2H)-ONE COMPOUNDS
-
Paragraph 0500, (2013/05/21)
8-Fluorophthalazin-1(2h)-one compounds of Formula II where one or two of X1, X2, and X3 are N, are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula II for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
REACTIONS OF 4-NITRO-1,2,3-TRIAZOLE WITH ALKYLATING AGENTS AND COMPOUNDS WITH ACTIVATED MULTIPLE BONDS
Vereshchagin, L. I.,Kuznetsova, N. I.,Kirillova, L. P.,Shcherbakov, V. V.,Sukhanov, G. T.,Gareev, G. A.
, p. 745 - 748 (2007/10/02)
When 4-nitro-1,2,3-triazole is alkylated, a mixture of N1- and N2-isomers is formed, with the latter usually predominating.The same behavior is also observed in addition reactions of 4-nitrotriazole to activated multiple bonds.
