1079655-16-5Relevant articles and documents
Discovery of P2X3 selective antagonists for the treatment of chronic pain
Cantin, Louis-David,Bayrakdarian, Malken,Buon, Christophe,Grazzini, Eric,Hu, Yun-Jin,Labrecque, Jean,Leung, Carmen,Luo, Xuehong,Martino, Giovanni,Paré, Michel,Payza, Kemal,Popovic, Nirvana,Projean, Denis,Santhakumar,Walpole, Christopher,Yu, Xiao Hong,Tomaszewski, Miros?aw J.
, p. 2565 - 2571 (2012/05/05)
Purinergic receptor P2X3 has been linked to analgesia in a number of pre-clinical models of pain, and is expressed in the human pain perception pathway. Only few P2X3-selective antagonists have been reported to date. This Letter describes the SAR and in vivo analgesic profile of a novel scaffold of selective P2X3 antagonists.