107967-01-1

Upstream product

• 107967-00-0 1,3,4,5-tetrahydro-7-chloro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 5367-28-2 5-chloro-2-nitrotoluene 
• 7443-25-6 dimethyl 2-(4-methoxybenzylidene)malonate 
• 107967-00-0 7-chloro-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 107966-98-3 [2-(5-chloro-2-nitrophenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid,dimethyl ester 
• 107966-99-4 [2-(2-amino-5-chlorophenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid,dimethyl ester 

Downstream Products

• 138383-37-6 (3R,4S-cis)-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one 
• 138337-22-1 (3S,4R-cis)-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one 
• 138337-22-1 cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one 
• 107967-02-2 trans-1,3,4,5-tetrahydro-7-chloro-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 138334-95-9 cis-1,3,4,5-tetrahydro-7-chloro-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 138334-33-5 cis-1,3,4,5-tetrahydro-7-chloro-3-acetoxy-1-<2-(dimethylamino)ethyl>-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 

Relevant academic research and scientific papers

Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site

We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the presenc

Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones

As part of a program to discover potent antihypertensive analogues of diltiazem (3a), we prepared 1-benzazepin-2-ones (4). Benzazepinones competitively displace radiolabeled diltiazem, and show the same absolute stereochemical preferences at the calcium channel receptor protein. Derivatives of 4 containing a trifluoromethyl substituent in the fused aromatic ring show potent and long-acting antihypertensive activity. Studies of the metabolism of 4 lead to the metabolically stable antihypertensive calcium channel blockers 5a and 5c. Benzazepinone 5a is a longer acting and more potent antihypertensive agent than the second generation diltiazem analogue TA-3090 (3e).

Benzazepine derivatives

Vasodilating activity is exhibited by compounds having the formula STR1 and pharmaceutically acceptable salts thereof.

3-substituted benzazepines

Benzazepine derivatives useful, for example, as cardiovascular agents, are disclosed. These compounds have the general formula STR1 and pharmaceutically acceptable salts thereof.