107975-82-6Relevant academic research and scientific papers
NOVEL PHARMACEUTICAL COMPRISING HETEROAROMATIC AMIDE DERIVATIVE OR SALT THEREOF
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Paragraph 1988-1989, (2021/09/17)
PROBLEM TO BE SOLVED: To provide a compound useful for treating or preventing disease associated with voltage-dependent sodium channel (Nav1.7) such as disease involving a pain, disease involving an itch, autonomic nerve-associated disease, or a pharmaceutical composition thereof. SOLUTION: The present disclosure provides a compound illustrated by the following formula, and a pharmaceutical composition containing the same. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
Macrocyclic lactone HMG-CoA reductase inhibitors
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, (2008/06/13)
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formula (I): STR1 are disclosed. Also disclosed are pharmaceutical compositions and methods of use of the compounds of formula (I).
Novel HMG-CoA reductase inhibitors
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, (2008/06/13)
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) or (II): STR1 wherein: n is 1 to 5; R is hydrogen or STR2 R1 is hydrogen or methyl; R2 is hydrogen or methyl; and R3 is hydrogen, C1-5 alkyl or C1-5 alkyl substituted with a member of the group consisting of phenyl, dimethylamino, or acetylamino; and the dotted lines at a, b and c represent optional double bonds and pharmaceutically acceptable salts of the compounds (II) in which R3 is hydrogen are disclosed.
KINETIC RESOLUTION OF LACTONES BY ENANTIOSELECTIVE PROTONATION OF THE CORRESPONDING CARBOXYLATE WITH A CHIRAL ACID
Fuji, Kaoru,Node, Manabu,Murata, Makoto,Terada, Shunji,Hashimoto, Keiji
, p. 5381 - 5382 (2007/10/02)
Racemic lactones were optically activated through the hydrolysis with sodium hydroxide followed by the partial neutralisation with (1S)-(+)-10-camphorsulfonic acid in ethanol to afford R- or S-isomer with 99 - 38percent ee.
