107976-58-9

Upstream product

• 132533-74-5 N,N'-bis(2-mesyloxyethyl)-N,N'-ditosyl-1,2-ethanediamine 
• 1074-82-4 potassium phtalimide 
• 56234-52-7 1,8-bis(p-toluenesulfonyloxy)-3,6-bis(p-toluenesulfonyl)-3,6-diazaoctane 
• 68-12-2 N,N-dimethyl-formamide 
• 115368-12-2 N³,N⁶-ditosyl-3,6-diaza-1,8-octanediol 
• 4403-78-5 ditosylethylenediamine 

Downstream Products

• 118852-31-6 4,7,13,16-tetratosyl-1,4,7,10,13,16-hexaazacyclooctadecane-2,9-dione 
• 107976-52-3 C₂₂H₃₀N₄O₆S₂ 
• 118852-30-5 N,N'-(ethane-1,2-diyl)bis 

Relevant academic research and scientific papers

An efficient route to symmetrically and unsymmetrically substituted azamacrocyclic ligands

An extremely efficient cyclisation protocol has been developed for the synthesis of symmetrically (6) and unsymmetrically substituted (7) derivatives of 1,4,7-triazacyclononane (2). The optimised conditions can be successfully applied to the synthesis of larger macrocycles 15a and 18a. In contrast, the protocol is not generally applicable with benzylamine, and the cyclic carbamates 16 and 19, rather than larger azamacrocycles, are formed, indicating that cyclisation in CH3CN using K2CO3 is highly specific to the formation of 7.

A convenient synthesis of macrocyclic lactams

A facile method is described for the synthesis of macrocyclic lactams using dicarboxylic acids and diamines directly in the presence of diphenylphosphoryl azide.