107983-87-9Relevant academic research and scientific papers
Enzymes in organic synthesis, 26: Synthesis of enantiomerically enriched 2,3- and 3,4-dimethylpentan-5-olides by lipase-catalyzed regio- and enantioselective alcoholysis of cis- and trans-2,3-dimethylpentanedioic anhydrides
Ozegowski, Ruediger,Kunath, Annamarie,Schick, Hans
, p. 1443 - 1448 (2007/10/03)
The enzyme-catalyzed regio- and enantioselective alcoholysis of racemic cis- and trans-2,3-dimethylpentanedioic anhydride in the presence of Novozym 435 from Candida antarctica afforded two of the eight possible monoesters with an enantiomeric excess higher than 90%. Regioselective reductions of these monoesters with lithium borohydride or borane/dimethyl sulfide furnished four enantiomerically highly enriched dimethylpentan-5-olides, which are versatile chiral intermediates. VCH Verlagsgesellschaft mbH, 1996.
A DIASTEREO- AND ENANTIOSELECTIVE MICHAEL ADDITION OF CHIRAL AMIDE ENOLATES TO α,β-UNSATURATED ESTERS; A STEREOSELECTIVE SYNTHESIS OF (+)-DEHYDROIRIDODIOL AND (-)-ISODEHYDROIRIDODIOL
Yamaguchi, Masahiko,Hasebe, Koichi,Tanaka, Shinya,Minami, Toru
, p. 959 - 962 (2007/10/02)
(+)-Dehydroiridodiol and (-)-isodehydroiridodiol were synthesized stereoselecticely using the diastereo- and enantioselective Michael addition of chiral amide enolates to α,β-unsaturated esters.
