1079989-93-7Relevant articles and documents
A new enantioselective catalytic route to Florhydral
Bovo, Sara,Scrivanti, Alberto,Bertoldini, Matteo,Beghetto, Valentina,Matteoli, Ugo
experimental part, p. 2547 - 2550 (2009/04/05)
The valuable fragrance Florhydral [3-(3-isopropylphenyl)butanal] has been synthesized in almost enantiomerically pure form by a new catalytic route. The key step of the process is the enantioselective hydrogenation of (E)-3-(3-isopropylphenyl)but-2-en-1-ol, which is carried out with asymmetric inductions of up to 97% using an iridium-phosphinooxazoline chiral catalyst. Georg Thieme Verlag Stuttgart.