108-23-6Relevant articles and documents
Vibrational conformational analysis of isopropyl fluoroformate
Veken, B. J. van der,Liefooghe, H. H.
, p. 257 - 292 (1991)
Infrared spectra of vapour and low temperature amorphous and crystalline phases, and Raman spectra of the vapour, liquid and low temperature crystalline phases of isopropyl fluoroformate (FCOOCH(CH3)2) and four isotopically substituted derivatives (FCOOCD(CH3)2, FCOOCH(CH3)(CD3), FCOOCH(CD3)2 and FCOOCD(CD3)2) are reported.The spectra indicate the presence of the same single conformer in each of these phases.Asymmetric top infrared contour simulation of the carbonyl streching vibration in methyl, tert-butyl and isopropyl fluoroformate shows that in the isopropylester the ester function has the s-cis conformation, while the isopropyl group shows a quasi-gauche orientation.
Atmospheric chemistry of isopropyl formate and tert-butyl formate
Pimentel, Andre Silva,Tyndall, Geoffrey S.,Orlando, John J.,Hurley, Michale D.,Wallington, Timothy J.,Andersen, Mads P. Sulbaek,Marshall, Paul,Dibble, Theodore S.
, p. 479 - 498 (2010)
Formates are produced in the atmosphere as a result of the oxidation of a number of species, notably dialkyl ethers and vinyl ethers. This work describes experiments to define the oxidation mechanisms of isopropyl formate, HC(O)OCH(CH3)2, and tert-butyl formate, HC(O)OC(CH 3)3. Product distributions are reported from both Cl- and OH-initiated oxidation, and reaction mechanisms are proposed to account for the observed products. The proposed mechanisms include examples of the α-ester rearrangement reaction, novel isomerization pathways, and chemically activated intermediates. The atmospheric oxidation of isopropyl formate by OH radicals gives the following products (molar yields): acetic formic anhydride (43%), acetone (43%), and HCOOH (15-20%). The OH radical initiated oxidation of tert-butyl formate gives acetone, formaldehyde, and CO2 as major products. IR absorption cross sections were derived for two acylperoxy nitrates derived from the title compounds. Rate coefficients are derived for the kinetics of the reactions of isopropyl formate with OH (2.4 ± 0.6) × 10-12, and with Cl (1.75 ± 0.35) × 10-11, and for tert-butyl formate with Cl (1.45 ± 0.30) × 10-11 cm3 molecule-1 s-1. Simple group additivity rules fail to explain the observed distribution of sites of H-atom abstraction for simple formates.
NOVEL VINBLASTINE DERIVATIVES, THEIR PREPARATION, USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID DERIVATIVES
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Page/Page column 38-39, (2010/05/13)
The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.
NOVEL DITHIOLOPYRROLONES AND THEIR THERAPEUTICAL APPLICATIONS
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Page/Page column 36, (2008/06/13)
The present invention provides novel dithiolopyrrolone compounds and their salts, which promote production of white blood cells and are useful as prevention and treatments for microbial infections such as HIV infection and blood disorders such as neutropenia and other related diseases. The present invention also provides therapeutic compositions comprising particularly useful types of dithiolopyrrolones, the salts thereof, and methods and use in the manufacture of a medication for treatment of diseases.
