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Usage

Uses

Used in Pharmaceutical Research and Drug Development:
2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide is used as a research compound for exploring its potential biological activities and therapeutic effects. Its indole-based structure and oxoacetamide functional group make it a promising candidate for further investigation in the development of new drugs targeting various diseases and conditions.
Used in Anticancer Applications:
Although not extensively studied, 2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide may be used as a potential anticancer agent due to the known anticancer properties of indole derivatives. Further research is needed to evaluate its efficacy in inhibiting tumor growth and progression, as well as its potential synergistic effects when combined with conventional chemotherapeutic drugs.
Used in Antimicrobial Applications:
Indole derivatives have demonstrated antimicrobial properties, and 2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide may be used as a potential antimicrobial agent. Further studies are required to assess its effectiveness against various microorganisms and its potential use in the development of new antimicrobial drugs.
Used in Anti-inflammatory Applications:
Given the anti-inflammatory properties of some indole derivatives, 2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide may also be explored for its potential use in anti-inflammatory applications. Further research is needed to determine its ability to modulate inflammatory pathways and its potential use in treating inflammatory diseases.

Upstream product

• 22980-10-5 (2-methyl-3-indolyl)glyoxyloyl chloride 
• 95-20-5 2-methyl-1H-indole 

Downstream Products

• 2731-06-8 2-methyltryptamine 

Relevant academic research and scientific papers

A new synthesis of versatile indolyl-3-carbonylnitriles

Abstract Indolyl-3-carbonylnitriles are compounds with demonstrated utility as intermediates in organic chemistry. However, their synthesis remains a challenge, requiring the use of toxic sources of cyanide, and often proceeding in low yields. Accordingly, presented here is a new synthesis of these versatile reactants, via dehydration of easily accessible α-oxoacetamides in generally high yields under simple reaction conditions.

A versatile linkage strategy for solid-phase synthesis of N,N-dimethyltryptamines and β-carbolines

(matrix presented) Various tryptamines are captured by a vinylsulfonylmethyl polystyrene resin, generating a safety-catch linkage. β-Carbolines can be formed from 4 by a Pictet-Spengler reaction with the introduction of R1. Tryptamine 4 can also be derivatized by acylation or copper-mediated coupling to introduce R2. If X = Br, Suzuki coupling can be used to introduce R3. After derivatization, the indole derivatives are activated with methyl iodide and released under mild basic condition.

Intermolecular trapping by indole of a spiroindolenine intermediate formed during the Bischler-Napieralski cyclisation of N-acetyltryptamine

The Bischler-Napieralski cyclisation of N-acetyltryptamine (1a) in the presence of indole (15) affords a moderate yield of the diastereomeric spiroindolines 9 and 10 suggesting the intermediacy of a spiroindolenine 2a in this reaction. Evidence is provided to show that the minor reaction products 2-methyltryptamine (11), tris-(3-indolyl)methane (12) and 6-[(o-aminophenyl) methyl]-5,11-dihydroindolo[3,2-b]carbazole (13) are derived from the spiroindolines 9 and 10.