1080-83-7

Basic information

• Product Name: 2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide
• Synonyms: 1H-indole-3-acetamide, 2-methyl-alpha-oxo-
• CAS NO: 1080-83-7
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.2093
• Mol File: 1080-83-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 459.1°C at 760 mmHg
• Flash Point: 231.4°C
• Density: 1.343g/cm³
• Vapor Pressure: 1.3E-08mmHg at 25°C
• Refractive Index: 1.681
• CAS DataBase Reference: 2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide(1080-83-7)
• EPA Substance Registry System: 2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide(1080-83-7)

Safety Data

• Hazardous Substances Data: 1080-83-7(Hazardous Substances Data)

Usage

General Description

2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide is a chemical compound with the molecular formula C12H11N3O2. It is a derivative of indole, a heterocyclic aromatic organic compound. 2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide is a synthetic derivative of indole and an oxoacetamide, which has potential applications in pharmaceutical research and drug development. Indole derivatives have been shown to exhibit a wide range of biological activities, including anticancer, antimicrobial, and anti-inflammatory properties. The specific properties and uses of 2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide have not been extensively studied, but it represents a potentially valuable compound for further research and development in the pharmaceutical industry.

Upstream product

• 22980-10-5 (2-methyl-3-indolyl)glyoxyloyl chloride 
• 95-20-5 2-methyl-1H-indole 

Downstream Products

• 2731-06-8 2-methyltryptamine 

Relevant articles and documents

A new synthesis of versatile indolyl-3-carbonylnitriles

Abstract Indolyl-3-carbonylnitriles are compounds with demonstrated utility as intermediates in organic chemistry. However, their synthesis remains a challenge, requiring the use of toxic sources of cyanide, and often proceeding in low yields. Accordingly, presented here is a new synthesis of these versatile reactants, via dehydration of easily accessible α-oxoacetamides in generally high yields under simple reaction conditions.

Intermolecular trapping by indole of a spiroindolenine intermediate formed during the Bischler-Napieralski cyclisation of N-acetyltryptamine

The Bischler-Napieralski cyclisation of N-acetyltryptamine (1a) in the presence of indole (15) affords a moderate yield of the diastereomeric spiroindolines 9 and 10 suggesting the intermediacy of a spiroindolenine 2a in this reaction. Evidence is provided to show that the minor reaction products 2-methyltryptamine (11), tris-(3-indolyl)methane (12) and 6-[(o-aminophenyl) methyl]-5,11-dihydroindolo[3,2-b]carbazole (13) are derived from the spiroindolines 9 and 10.