1080-87-1

Basic information

• Product Name: Pyrazineacetonitrile, a-phenyl-
• CAS NO: 1080-87-1
• Molecular Formula: C12H9N3
• Molecular Weight: 195.224
• Mol File: 1080-87-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Pyrazineacetonitrile, a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazineacetonitrile, a-phenyl-(1080-87-1)
• EPA Substance Registry System: Pyrazineacetonitrile, a-phenyl-(1080-87-1)

Safety Data

• Hazardous Substances Data: 1080-87-1(Hazardous Substances Data)

Upstream product

• 3149-28-8 2-methoxypyrazine 
• 140-29-4 phenylacetonitrile 
• 14508-49-7 2-chloropyrazin 

Downstream Products

• 3430-09-9 phenyl(pyrazin-2-yl)methanone 
• 4190-80-1 2-phenyl-2-pyrazin-2-yl-succinonitrile 
• 109929-54-6 2-Phenyl-3-phenylsulfanyl-2-pyrazin-2-yl-propionitrile 
• 4422-44-0 2-phenyl-2-pyrazin-2-yl-pentanedinitrile 
• 109929-53-5 2-Phenyl-2-pyrazin-2-yl-hexanenitrile 
• 109929-57-9 4-Oxo-2,4-diphenyl-2-pyrazin-2-yl-butyronitrile 
• 109929-61-5 3-(4-Methoxy-phenyl)-2-phenyl-2-pyrazin-2-yl-propionitrile 
• 109929-58-0 3-Benzotriazol-1-yl-2-phenyl-2-pyrazin-2-yl-propionitrile 
• 109929-59-1 2-Phenyl-2-pyrazin-2-yl-3-pyridin-2-yl-propionitrile 
• 109929-56-8 3-(4-Nitro-phenyl)-2-phenyl-2-pyrazin-2-yl-propionitrile 
• 109929-55-7 2-Phenyl-2-pyrazin-2-yl-3-p-tolyl-propionitrile 
• 109929-60-4 2,4-Diphenyl-2-pyrazin-2-yl-butyronitrile 

Relevant articles and documents

Preparation of Heteroaryl Phenylmethanes and a 13C and 15N NMR Spectroscopic Study of their Conjugate Carbanions. Rotational Isomerism and Charge Maps of the Anions and Ranking of the Charge Demands of the Heterocycles

2-Benzylpyridazine, 4-benzylpyrimidine, 2-benzylpyrimidine and 2-benzylpyrazine, (5-8) have been prepared in order to study their 13C and 15N spectra and those of their conjugate carbanions (1-4).These systems are aza-homologues of the previously reported

A New Synthesis of Aryl Hetaryl Ketones via SRN1 Reaction of Halogenated Heterocycles withPotassiophenylacetonitrile Followed by Phase-Transfer Catalyzed Decyanation

Reaction of halogenated pyridines, quinolines, pyrimidines, and pyrazines with potassiophenylacetonitrile (5) in liquid ammonia under near-uv irradiation affords secondary nitriles, which then undergo oxidative decyanation under phase-transfer catalytic conditions to afford aryl hetaryl ketones in excellent yields.

SRN1 Mechanism in Heteroaromatic Nucleophilic Substitution. Reactions Involving Halogenated Pyrimidines, Pyridazines, and Pyrazines

Reactions of 2-chloropyrimidine (1), 4-chloro-2,6-dimethoxypyrimidine (7), 3-chloro-6-methoxypyridazine (9), and 2-chloropyrazine (14) with a representative series of ketone enolates in liquid ammonia exhibited characteristics consistent with a radical-chain (SRN1) mechanism for substituton.Diazines 1 and 9 showed an unexpected sensitivity to enolate ion structure, with 1 reacting best with tertiary enolates and 9 undergoing substitution most satisfactorily with primary enolates.The order of SRN1 reactivity among the various substrates was found to be 14 > 9 > 7 =ca. 1.Thus 1 and 7 required photostimulation at 35o nm for satisfactory displacemement of chloride, 9 underwent some substitution without illumination, and 14 reacted smoothly in the dark.