1080004-48-3Relevant academic research and scientific papers
An Ireland-Claisen approach to β-alkoxy α-amino acids
Tellam, James P.,Kociok-Koehn, Gabriele,Carbery, David R.
, p. 5199 - 5202 (2008)
(Chemical Equation Presented) A diastereoselective Ireland-Claisen approach to β-alkoxy α-amino acid esters is reported. Amino acid esters of enol ethereal allylic alcohols undergo facile syn-selective [3,3]-sigmatropic rearrangement via silyl ketene acetals. Substrate synthesis, rearrangement development, stereoselectivity, and product elaboration are discussed.
