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dimethylthexylsilyl 6-O-{4,6-O-benzylidene-2-deoxy-2-[(R)-3-hexadecanoyloxy-15-methylhexadecanoylamino]-3-O-levulinoyl-β-D-glucopyranosyl}-3-O-allyloxycarbonyl-2-azido-4-O-benzyl-2-deoxy-β-D-glucopyranoside is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1080017-75-9

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1080017-75-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1080017-75-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,0,0,1 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1080017-75:
(9*1)+(8*0)+(7*8)+(6*0)+(5*0)+(4*1)+(3*7)+(2*7)+(1*5)=109
109 % 10 = 9
So 1080017-75-9 is a valid CAS Registry Number.

1080017-75-9Downstream Products

1080017-75-9Relevant academic research and scientific papers

Synthetic tetra-acylated derivatives of lipid a from Porphyromonas gingivalis are antagonists of human TLR4

Zhang, Yanghui,Gaekwad, Jidnyasa,Wolfert, Margreet A.,Boons, Geert-Jan

experimental part, p. 3371 - 3381 (2009/02/05)

Tetra-acylated lipid As derived from Porphyromonas gingivalis LPS have been synthesized using a key disaccharide intermediate functionalized with levulinate (Lev), allyloxycarbonate (Alloc) and anomeric dimethylthexylsilyl (TDS) as orthogonal protecting groups and 9-fluorenylmethoxycarbamate (Fmoc) and azido as amino protecting groups. Furthermore, an efficient cross-metathesis has been employed for the preparation of the unusual branched R-(3)-hydroxy-13-methyltetradecanic acid and (R)-3-hexadecanoyloxy-15- methylhexadecanoic acid of P. gingivalis lipid A. Biological studies have shown that the synthetic lipid As cannot activate human and mouse TLR2 and TLR4 to produce cytokines. However, it has been found that the compounds are potent antagonist of cytokine secretion by human monocytic cells induced by enteric LPS.

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