1080028-51-8Relevant articles and documents
Synthesis and antiproliferative activity of unnatural enantiomers of 7-epi-goniofufurone and crassalactone C
Popsavin, Velimir,Benedekovic, Goran,Sreco, Bojana,Popsavin, Mirjana,Francuz, Jovana,Kojic, Vesna,Bogdanovic, Gordana
, p. 5178 - 5181 (2008)
A facile synthesis of 7-epi-(-)-goniofufurone as well as the first synthesis of (-)-crassalactone C was achieved starting from d-xylose. A comparison of their in vitro antitumour activities with those observed for the corresponding naturally occurring enantiomers was provided.
Enantiodivergent synthesis of cytotoxic styryl lactones from d-xylose. The first total synthesis of (+)- and (-)-crassalactone C
Popsavin, Velimir,Benedekovi?, Goran,Sre?o, Bojana,Francuz, Jovana,Popsavin, Mirjana,Koji?, Vesna,Bogdanovi?, Gordana,Divjakovi?, Vladimir
experimental part, p. 10596 - 10607 (2010/03/03)
Enantiodivergent total syntheses of both (+)- and (-)-enantiomers of goniofufurone, 7-epi-goniofufurone and crassalactone C have been accomplished starting from d-xylose. The key steps of the synthesis of 7-epi-(+)-goniofufurone were a stereo-selective ad
Design, synthesis and antiproliferative activity of two new heteroannelated (-)-muricatacin mimics
Popsavin, Velimir,Sreco, Bojana,Benedekovic, Goran,Popsavin, Mirjana,Francuz, Jovana,Kojic, Vesna,Bogdanovic, Gordana
scheme or table, p. 5182 - 5185 (2009/05/07)
Two new (-)-muricatacin mimics bearing a furano-furanone ring and an oxygen isostere in the side chain have been designed and synthesized and their in vitro antiproliferative activity was evaluated against several human tumour cell lines. Both analogues showed an increased activity against HL-60 cells with 17- and 185-fold higher potency than (-)-muricatacin. A straightforward synthesis of (-)-muricatacin is also disclosed.