108015-89-0Relevant academic research and scientific papers
Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6
Sharma, Simmi,Gupta, Shilpa,Khajuria, Vidushi,Bhagat, Asha,Ahmed, Zabeer,Shah, Bhahwal Ali
, p. 695 - 698 (2016)
A library of boswellic acid analogues were synthesized and tested for their anti-inflammatory potential on key inflammatory mediators, TNF-α and IL-6. The study led to the identification of lead compounds showing significant inhibition of the cytokines, TNF-α and IL-6 both in vitro and in vivo.
Design, synthesis and biological evaluation of β-boswellic acid based HDAC inhibitors as inducers of cancer cell death
Sharma, Simmi,Ahmad, Mudassier,Bhat, Javeed Ahmad,Kumar, Arvind,Kumar, Manjeet,Zargar, Mohmmad Afzal,Hamid, Abid,Shah, Bhahwal Ali
, p. 4729 - 4734 (2014)
The synthesis and bio-evaluation of naturally occurring boswellic acids (BAs) as an alternate CAP for the design of new HDAC inhibitors is described. All the compounds were screened against a panel of human cancer cell lines to identify leads, which were subsequently examined for their potential to inhibit HDACs. The identified lead compound showed IC50value of 6 μm for HDACs, found to induce G1cell cycle arrest at significantly low concentration (1 μM) and caused significant loss in mitochondrial membrane potential at 5 and 10 μM. Furthermore, specific interactions of the lead molecule inside the catalytic domain were also studied through in silico molecular modeling.
