108032-13-9

Basic information

• Product Name: 1,2-dipalmitoyl-3-succinylglycerol
• Synonyms: 1,2-dipalmitoyl-3-succinylglycerol;1,2-dipalMitoyl-sn-glycero-3-succinate
• CAS NO: 108032-13-9
• Molecular Formula: C39H72O8
• Molecular Weight: 668.98418
• Mol File: 108032-13-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 691°Cat760mmHg
• Flash Point: 191.3°C
• Appearance: /
• Density: 0.987g/cm³
• Vapor Pressure: 6.56E-21mmHg at 25°C
• Refractive Index: 1.471
• PKA: 4.33±0.17(Predicted)
• CAS DataBase Reference: 1,2-dipalmitoyl-3-succinylglycerol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dipalmitoyl-3-succinylglycerol(108032-13-9)
• EPA Substance Registry System: 1,2-dipalmitoyl-3-succinylglycerol(108032-13-9)

Safety Data

• Hazardous Substances Data: 108032-13-9(Hazardous Substances Data)

Usage

General Description

1,2-dipalmitoyl-3-succinylglycerol is a synthetic lipid molecule composed of two palmitic acid molecules attached to a glycerol backbone with a succinyl group. It is often used in the development of liposome-based drug delivery systems and as a surfactant in various formulations. This chemical has been studied for its potential as a vehicle for delivering therapeutic agents, due to its ability to form stable lipid bilayers and its biocompatibility. It has also been investigated for its antimicrobial properties and potential use in the development of antibacterial agents. Overall, 1,2-dipalmitoyl-3-succinylglycerol has shown promise in various applications related to drug delivery and antimicrobial activity.

InChI:InChI=1/C39H72O8/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-37(42)45-33-35(34-46-38(43)32-31-36(40)41)47-39(44)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h35H,3-34H2,1-2H3,(H,40,41)/t35-/m1/s1

Upstream product

• 108-30-5 succinic acid anhydride 
• 30334-71-5 1,2-dipalmitoyl-sn-glycerol 

Relevant articles and documents

Lipopeptides incorporated into supported phospholipid monolayers have high specific activity at low incorporation levels

The ability to present cell adhesion molecule (CAM) ligands in controlled amounts on a culture surface would greatly facilitate the control of cell growth and differentiation. Supported lipid monolayer/bilayer systems have previously been developed that allow for presentation of CAM ligands for cell interaction; however, these systems have employed peptide loadings much higher than those used in poly-(ethylene glycol) (PEG)-based immobilization systems. We report the development of synthetic methods that can be used for the efficient and versatile creation of many linear and cyclic lipid-linked peptide moieties. Using RGD-based peptides for the α5β1 integrin as a model system, we have demonstrated that these lipopeptides support efficient cell binding and spreading at CAM ligand loadings as low as 0.1 mol %, which is well below that previously reported for supported lipid systems. Engineered lipopeptide-based surfaces offer unique presentation options not possible with other immobilization systems, and the high activity at low loadings we have shown here may be extremely useful in presenting multiple CAM ligands for studying cell growth, differentiation, and signaling.