108035-44-5

Basic information

• Product Name: Benzoic acid, 4-(2-methyl-1H-imidazol-1-yl)-, ethyl ester
• CAS NO: 108035-44-5
• Molecular Formula: C13H14N2O2
• Molecular Weight: 230.266
• Mol File: 108035-44-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(2-methyl-1H-imidazol-1-yl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(2-methyl-1H-imidazol-1-yl)-, ethyl ester(108035-44-5)
• EPA Substance Registry System: Benzoic acid, 4-(2-methyl-1H-imidazol-1-yl)-, ethyl ester(108035-44-5)

Safety Data

• Hazardous Substances Data: 108035-44-5(Hazardous Substances Data)

Upstream product

• 693-98-1 2-methylimidazole 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 125903-27-7 N-<2-(diethylamino)ethyl>-4-(2-methyl-1H-imidazol-1-yl)benzamide 
• 167758-58-9 4-(2-Methyl-1H-imidazol-1-yl)benzenemethanol 
• 1428369-11-2 ethyl 1-methyl-4,5-diphenylimidazo[1,5-a]quinoline-7-carboxylate 
• 1400708-23-7 N-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]-N-cyclopropyl-4-(2-methylimidazol-1-yl)benzamide 
• 1400708-06-6 N-cyclopropyl-N-(3'-fluoro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-4-(2-methylimidazol-1-yl)benzamide 
• 101184-07-0 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)benzoyl]-2H-imidazol-2-one 
• 101184-11-6 4-(2-methyl-1H-imidazol-1-yl)benzoic acid 

Relevant articles and documents

Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase

Replacement of the dihydroquinolinone pharmacophore of Zeneca's ZD2138 by ionizable imidazolylphenyl moiety has lead to the discovery of a novel series of potent and orally active 5-lipoxygenase (5-LO) inhibitors. The synthesis and structure-activity relationship (SAR) of this series of compounds are described herein.

New compounds, pharmaceutical compositions and uses thereof

The present invention relates to compounds of general formula I, wherein the groups R1, LP, LQ, Ar, m and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

5-lipoxygenase inhibitors

Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: STR1 and the pharmaceutically acceptable salts thereof, wherein Ar1 is a heterocyclic moiety which is selected from imidazolyl, pyrrolyl, py