108035-45-6

Basic information

• Product Name: 4-(1H-IMIDAZOL-2-YL)-BENZOIC ACID
• Synonyms: 4-(2-Imidazolyl)-benzoic Acid;Benzoicacid,4-(1H-iMidazol-2-yl)-;4-(Imidazol-2-yl)benzoic acid
• CAS NO: 108035-45-6
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.19
• Mol File: 108035-45-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: >350 °C(Solv: N,N-dimethylformamide (68-12-2))
• Boiling Point: 471.5°C at 760 mmHg
• Flash Point: 239°C
• Appearance: /
• Density: 1.355g/cm³
• Vapor Pressure: 1.08E-09mmHg at 25°C
• Refractive Index: 1.644
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.36±0.10(Predicted)
• CAS DataBase Reference: 4-(1H-IMIDAZOL-2-YL)-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-IMIDAZOL-2-YL)-BENZOIC ACID(108035-45-6)
• EPA Substance Registry System: 4-(1H-IMIDAZOL-2-YL)-BENZOIC ACID(108035-45-6)

Safety Data

• Hazardous Substances Data: 108035-45-6(Hazardous Substances Data)

Usage

Uses

4-(1H-Imidazol-2-yl)benzoic acid

InChI:InChI=1/C10H8N2O2/c13-10(14)8-3-1-7(2-4-8)9-11-5-6-12-9/h1-6H,(H,11,12)(H,13,14)

Upstream product

• 131543-46-9 Glyoxal 
• 619-66-9 4-Carboxybenzaldehyde 

Downstream Products

• 125903-40-4 N-<2-(diethylamino)ethyl>-4-(1H-imidazol-2-yl)benzamide 
• 108035-39-8 4-[4-(1H-Imidazol-2-yl)-benzoyl]-5-methyl-1,3-dihydro-imidazol-2-one 
• 94444-69-6 4-ethyl-1,3-dihydro-5-[4-(1H-imidazol-2-yl)benzoyl]-2H-imidazol-2-one 
• 125903-39-1 4-(1H-imidazol-2-yl)benzoic acid methyl ester 
• 1022158-41-3 (4-(1H-imidazol-2-yl)phenyl)methanol 

Relevant articles and documents

A sustainable approach towards the three-component synthesis of unsubstituted 1H-imidazoles in the water at ambient conditions

A green protocol for the synthesis of unsubstituted imidazoles has been demonstrated herein. The reaction is realized using commercially available lipase enzyme, porcine pancreas lipase (PPL) in water. The reaction conditions are selective and mild which helped to tolerate a wide variety of functional groups to give the desired products in good chemical yields. (Figure presented.).

Inhibitors of histone deacetylase

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.