108050-54-0

Basic information

• Product Name: Tilmicosin
• Synonyms: 20-DEOXO-20-(3,5-DIMETHYL-1-PIPERIDINYL)DESMYCOSIN;TILMICOSIN;Tilmicosin, Vetranal;Tilmicosine;Tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-.alpha.-L-ribo-hexopyranosyl)-20-deoxo-20-(3R,5S)-3,5-dimethyl-1-piperidinyl-;pulmotil;4A-O-De(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]tylosin;Antibiotic EL 870
• CAS NO: 108050-54-0
• Molecular Formula: C46H80N2O13
• Molecular Weight: 869.13
• EINECS: 1806241-263-5
• Product Categories: Active Pharmaceutical Ingredients;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;API
• Mol File: 108050-54-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 926.6 °C at 760 mmHg
• Flash Point: 514.2 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: 0-6°C
• Solubility: Acetone (Slightly), DMSO (Slightly), Methanol (Sparingly)
• PKA: pKa (66% DMF): 7.4, 8.5(at 25℃)
• CAS DataBase Reference: Tilmicosin(CAS DataBase Reference)
• NIST Chemistry Reference: Tilmicosin(108050-54-0)
• EPA Substance Registry System: Tilmicosin(108050-54-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 108050-54-0(Hazardous Substances Data)

Usage

Brief introduction

Tilmicosin is a relatively novel semi-synthetic macrolide antibiotics derived from tylosin for being applied to livestock and poultry. The chemical name is 4A-O-de (2, 6-dideoxy-methyl-3-C--L-ribose-pyran-hexyl)-20-deoxy-20-(3,5-dimethyl-1-piperidinyl)-[20 (cis: trans)] tylosin. Molecule formula is C46H80N2O13 and the molecular weight of 869.15. Tilmicosin has a similar antibacterial spectrum as tylosin but has enhanced effect on the anti-Pasteurella multocida and hemolytic pasteurella. It was successfully developed in 1980s and initially used with a code of EL-870. Common trade names include Pulmotil ? Micotil ?, preparations include tilmicosin soluble powder, premix (20%) preparation, and injection. In 1990 it was approved in most European countries; it was approved in the US in 1992, and included in USP. China also has some domestic enterprises approved for production of tilmicosin. Because of its special antibacterial activity and pharmacokinetic characteristics, the drug has been approved for clinical prevention and treatment of infectious diseases for cattle, goats, sheep, cows, pigs, and chickens. It is especially applied to the treatment of respiratory diseases of livestock, such as cattle Actinobacillus pleuropneumonia, Pasteurella disease, chicken mycoplasmosis and mastitis of lactating animals. The above information is edited by the lookchem of Dai Xiongfeng.

Chemical Properties

Different sources of media describe the Chemical Properties of 108050-54-0 differently. You can refer to the following data:
1. It is white or white powder with humidity: ≤5.0%.
2. White Solid

Uses

Different sources of media describe the Uses of 108050-54-0 differently. You can refer to the following data:
1. It can be used as anti-bacterial. It is mainly used for the treatment of infection caused by pleuropneumonia, Actinobacillus, Pasteurella and mycoplasma.
2. Tilmicosin is a semi-synthetic antibiotic derived from desmycosin (tylosin B), a minor co-metabolite of tylosin. Tilmicosin is produced by reductive amination of desmycosin. Desmycosin itself is prepared by the partial hydrolysis of tylosin with the loss of the mycarosyl sugar. The piperidinyl group at C20 of tilmicosin provides a wider spectrum of antibiotic action, in particular good protection against Pasteurella in livestock.
3. A Macrolide antibiotic.
4. Macrolide antibiotic structurally related to tylosin. Antibacterial

Veterinary Drugs and Treatments

Tilmicosin is indicated for the treatment of bovine or ovine respiratory diseases (BRD) caused by Mannheimia (Pasturella) haemolytica.

InChI:InChI=1/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1

Related news

Original ResearchEffects of Tilmicosin (cas 108050-54-0) Phosphate Administration on Echocardiographic Parameters in Healthy Donkeys (Equus asinus): An Experimental Study08/29/2019

The aim of this study was to evaluate the effect of tilmicosin on echocardiographic measurements in donkeys. For this purpose, placebo and tilmicosin 30% (10 mg/kg) were administered subcutaneously to clinically healthy donkeys (n = 10) in a randomized prospective crossover study. Cardiac functi...detailed

Effects of nasal instillation of a nitric oxide-releasing solution or parenteral administration of Tilmicosin (cas 108050-54-0) on the nasopharyngeal microbiota of beef feedlot cattle at high-risk of developing respiratory tract disease08/28/2019

Nitric oxide has bactericidal and virucidal properties. Nasal instillation of a nitric oxide releasing solution (NORS) on arrival at the feedlot was recently reported as inferior to a parenteral injection of tilmicosin (macrolide antibiotic) for control of bovine respiratory disease (BRD) in cat...detailed

ResearchEffects of oral Tilmicosin (cas 108050-54-0) on health and performance in newly received beef heifers08/26/2019

ABSTRACTThe objective of these studies was to determine the effects of feeding tilmicosin on health and performance of newly received beef cattle. Beef heifers (n = 480) were used in 2 studies to determine effects of oral tilmicosin on health and performance. In Exp. 1, 320 heifers (BW = 196 ± ...detailed

Microstructure and antioxidative capacity of the microalgae mutant Chlorella PY-ZU1 during Tilmicosin (cas 108050-54-0) removal from wastewater under 15% CO208/25/2019

The response mechanisms of microalgal mutant Chlorella PY-ZU1 cells were investigated in their removal of antibiotic tilmicosin from wastewater under 15% CO2. Low concentrations (0.01–2 mg L−1) of tilmicosin in wastewater stimulated the growth of microalgal cells, whereas high concentrations (5...detailed

Microbiological toxicity of Tilmicosin (cas 108050-54-0) on human colonic microflora in chemostats08/24/2019

To evaluate the microbiological safety of tilmicosin on human intestinal microflora, four chemostat models of healthy human colonic ecosystems were exposed to tilmicosin (0, 0.436, 4.36, and 43.6 μg/mL) for 7 days. Prior to and during drug exposure, three microbiological endpoints were monitore...detailed

Preparation and evaluation of Tilmicosin (cas 108050-54-0) microspheres and lung-targeting studies in rabbits08/22/2019

Tilmicosin (TMS) is a macrolide used extensively for pulmonary infections in clinical veterinary medicine. However, TMS has frequent administration and short elimination half-life. Therefore, tilmicosin–gelatine microspheres (TMS–GMS) were prepared by an emulsion-chemical cross-linking techniq...detailed