1080602-67-0

Basic information

• Product Name: 4-(3-bromo-5-nitro-phenyl)-1H-indole
• Synonyms: 4-(3-bromo-5-nitro-phenyl)-1H-indole
• CAS NO: 1080602-67-0
• Molecular Weight: 317.142
• Mol File: 1080602-67-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(3-bromo-5-nitro-phenyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-bromo-5-nitro-phenyl)-1H-indole(1080602-67-0)
• EPA Substance Registry System: 4-(3-bromo-5-nitro-phenyl)-1H-indole(1080602-67-0)

Safety Data

• Hazardous Substances Data: 1080602-67-0(Hazardous Substances Data)

Upstream product

• 827-94-1 2,6-dibromo-4-nitroaniline 
• 6311-60-0 3,5-dibromonitrobenzene 
• 220465-43-0 indole-4-boronic acid 

Relevant articles and documents

ANTI-CANCER AGENTS ANS USES THEREOF

The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula (I): and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3 R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6- 10 carbons in the ring portion, an optionally-substituted 6- membered heteroaryl group having 1- 3 nitrogen atoms in the ring portion, an optionally-substituted 5- membered heteroaryl group having 0- 4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6- membered ring is fused either to a 5- membered ring or to a 6- membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, prostate, non-small cell lung and colon. They are additionally useful in the treatment of proliferative retinopathies such as diabetic neuropathy and macular degeneration.