108061-47-8

Basic information

• Product Name: 7-Bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• Synonyms: 7-Bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• CAS NO: 108061-47-8
• Molecular Formula: C11H11BrN2
• Molecular Weight: 251.12244
• Mol File: 108061-47-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 7-Bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(108061-47-8)
• EPA Substance Registry System: 7-Bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(108061-47-8)

Safety Data

• Hazardous Substances Data: 108061-47-8(Hazardous Substances Data)

Usage

General Description

7-Bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole is a chemical compound that belongs to the class of pyridine alkaloids. It is a bicyclic heterocyclic compound containing a pyridine ring and an indole ring. 7-Bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole has a bromine group attached to the pyridine ring, and its molecular formula is C11H11BrN2. This chemical has potential applications in medicinal chemistry and pharmaceutical research due to its structural features and potential biological activities. Further research on this compound may reveal its pharmacological properties and potential therapeutic uses.

Upstream product

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• 27246-81-7 3-bromophenylhydrazine hydrochloride 
• 222173-67-3 3-<(E)-2-nitroethenyl>-6-bromoindole 
• 60956-26-5 4-bromo-2-nitrotoluene 
• 52415-29-9 6-bromo-1H-indole 
• 127286-63-9 7-bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid 

Downstream Products

• 88704-40-9 7-bromo-9H-pyrido[3,4-b]indole 

Relevant articles and documents

Binding of β-carbolines at 5-HT2 serotonin receptors

A series of ring-substituted (i.e., methoxy and bromo) 3,4-dihydro- and 1,2,3,4-tetrahydro-β-carbolines was examined at 5-HT2A and 5-HT2C serotonin receptors. Whereas most of the methoxy-substituted derivatives typically displayed affinities similar to their unsubstituted parents, certain (particularly 8-substituted) bromo derivatives displayed enhanced affinity. A binding profile was obtained for selected β-carbolines.

Tetrahydrocarboline analogs as MCH-1 antagonists

A new series of tetrahydrocarbolines with potent MCH-1 antagonist activity were synthesized, using a conformationally constrained design approach towards optimizing pharmacokinetic properties. Two compounds from this series were progressed to a 5-day diet-induced obesity mouse screening model to evaluate their potential as weight loss agents. Both compounds produced a highly significant reduction in weight, which was attributed to their improved pharmacokinetic profile.