1080643-39-5Relevant academic research and scientific papers
Proline ureas: Synthesis and pharmacological evaluation as VLA-4 antagonists
Sattigeri, Viswajanani J.,Soni, Ajay,Dastidar, Sunanda G.,Ray, Abhijit,Ahmad, Sharif,Gupta, Jung B.,Salman, Mohammad
, p. 2004 - 2020 (2008/09/18)
VLA-4 has been identified as a relatively new target for the development of "non-steroidal" alternatives for the treatment of asthma and related respiratory inflammatory diseases. In continuation of search to identify potent VLA-4 antagonists, a series of novel proline urea derivatives have been synthesized. The newly synthesized compounds are evaluated as potential VLA-4 antagonists in vitro and are found to exhibit moderate VLA-4 inhibitory activity.
