1080656-96-7

Upstream product

• 19315-93-6 quinoline-2,6-diol 
• 100-44-7 benzyl chloride 

Downstream Products

• 1374108-23-2 C₁₇H₁₂F₃NO₄S 
• 1374107-09-1 2-(4-diethylaminophenyl)-6-(1-fluoromethyl-2-hydroxy)quinoline hydrochloride 
• 1374107-63-7 2-(4-diethylaminophenyl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline 
• 1374108-24-3 C₂₆H₂₆N₂O 
• 1374108-25-4 C₁₉H₂₀N₂O 
• 1374108-26-5 C₂₉H₃₁FN₂O₂ 
• 1374107-08-0 2-(4-diethylaminophenyl)-6-(1-fluoromethyl-2-hydroxy)quinoline 
• 1374109-33-7 C₃₅H₄₆N₂O₅SSi 
• 1374109-32-6 C₂₉H₃₂N₂O₅S 

Relevant academic research and scientific papers

TAU IMAGING PROBE

An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.

ORGANIC COMPOUNDS

The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.