1080675-72-4

Basic information

• Product Name: 1-(4-fluoro-2-phenylamino-phenyl)-3-(4-methanesulfonyl-piperidin-1-yl)-propan-1-one
• Synonyms: 1-(4-fluoro-2-phenylamino-phenyl)-3-(4-methanesulfonyl-piperidin-1-yl)-propan-1-one
• CAS NO: 1080675-72-4
• Molecular Weight: 404.506
• Mol File: 1080675-72-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-fluoro-2-phenylamino-phenyl)-3-(4-methanesulfonyl-piperidin-1-yl)-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluoro-2-phenylamino-phenyl)-3-(4-methanesulfonyl-piperidin-1-yl)-propan-1-one(1080675-72-4)
• EPA Substance Registry System: 1-(4-fluoro-2-phenylamino-phenyl)-3-(4-methanesulfonyl-piperidin-1-yl)-propan-1-one(1080675-72-4)

Safety Data

• Hazardous Substances Data: 1080675-72-4(Hazardous Substances Data)

Upstream product

• 1080675-70-2 4-fluoro-N-methoxy-N-methyl-2-phenylamino-benzamide 
• 365-54-8 4-fluoro-2-phenylamino-benzoic acid 
• 1080675-71-3 1-(4-fluoro-2-phenylamino-phenyl)-propenone 
• 290328-55-1 4-(methylsulfonyl)piperidine 

Downstream Products

• 1080674-54-9 7-fluoro-3-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester 

Relevant articles and documents

Discovery of a novel series of 4-quinolone JNK inhibitors

A novel series of highly selective JNK inhibitors based on the 4-quinolone scaffold was designed and synthesized. Structure based drug design was utilized to guide the compound design as well as improvements in the physicochemical properties of the series. Compound (13c) has an IC50 of 62/170 nM for JNK1/2, excellent kinase selectivity and impressive efficacy in a rodent asthma model.