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108086-47-1

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108086-47-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 108086-47-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,0,8 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 108086-47:
(8*1)+(7*0)+(6*8)+(5*0)+(4*8)+(3*6)+(2*4)+(1*7)=121
121 % 10 = 1
So 108086-47-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H12ClN3O2/c17-11-5-7-12(8-6-11)19-15(21)9-20-10-18-14-4-2-1-3-13(14)16(20)22/h1-8,10H,9H2,(H,19,21)

108086-47-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(4-chlorophenyl)-2-(4-oxoquinazolin-3-yl)acetamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:108086-47-1 SDS

108086-47-1Downstream Products

108086-47-1Relevant articles and documents

Synthesis and antiproliferative evaluation of oxime, methyloxime, and amide-containing quinazolinones

Chang, Ken-Ming,Chen, Li-Chai,Tzeng, Cherng-Chyi,Lu, Yao-Hua,Chen, I-Li,Juang, Shin-Hun,Wang, Tai-Chi

, p. 1110 - 1118 (2018/05/30)

Certain oxime, methyloxime, and amide-containing quinazolinone derivatives were synthesized and evaluated in vitro for their antiproliferative activities against a panel of human cancer cell lines including nasopharyngeal carcinoma (NPC-TW01), lung carcinoma (NCI-H226), and leukemia (Jurkat). Quinazolinone 2 was inactive against all three cell lines tested, while quinazolinone 4 was weakly active against both Jurkat and H226 cancer cells with IC50 values of 6.55 and 12.27 μM, respectively, indicating that the oxime derivative 4 is more favorable than its ketone precursor 2. Our results have also indicated that quinazolinone 8g and its biphenyl counterpart 8f exhibited more potent antiproliferative activities than the positive control methotrexate against all three cancer cell lines tested. Among these quinazolinone derivatives, 8g was the most active against NPC-TW01 with an IC50 value of 4.78 μM. Further study on NPC-TW01 cell cycle distribution indicated that the compound 8g induced cell arrest at the G1/G0 phase in a time- and concentration-dependent manner. Moreover, a characteristic hypo-diploid DNA content peak (sub-G1) was found to increase from 1 to 4% in NPC-TW01 cells treated with 8g for 72 hr. These results indicate that 8g can induce cells arrest in the G1/G0 phase and cause cell death. Further structural optimization of 8g and detailed study of its antiproliferative mechanism are going on.

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