108091-31-2Relevant academic research and scientific papers
Di-heterocyclic compounds and their use as antiviral agents
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, (2008/06/13)
Compounds of the formulas: STR1 wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.
Structure-Activity Studies of 5-alkyl>-3-methylisoxazoles: Inhibitors of Picornavirus Uncoating
Diana, Guy D.,Oglesby, Richard C.,Akullian, Vahan,Carabateas, Phillip M.,Cutcliffe, David,et al.
, p. 383 - 388 (2007/10/02)
A series of substituted phenyl analogues of 5-alkyl>-3-methylisoxazoles has been synthesized and evaluated in vitro against several human rhinovirus (HRV) serotypes.Substituents in the 2-position greatly enhanced activi
