108098-48-2Relevant academic research and scientific papers
Piperaziniocephalosporins
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, (2008/06/13)
Antibacterial hydroxyarylpiperazinocephalosporins of the formula: STR1 wherein R1 is amino or acylamino; R2 is H or methoxy; R3 is alkyl; R4 is --(P--C--Q)n --, where P and Q each are H, alkyl or OH, or P and Q combine to form oxo, and n is 0 or 4; R5 is substituted or unsubstituted hydroxyaryl; R6 has a negative charge and is COO, or an anion in combination with an optionally protected carboxy; and X is O, S or S→O; an antibacterial preparation containing the same; a method for killing bacteria and preventing or treating bacterial infection by using the same; and syntheses of the cephalosporins are provided.
Pharmacokineticts of Catechol Cephalosporins. The Effect of Incorporating Substituents into the Catechol Moiety on Pharmacokinetics in a Marmoset Model
Bird, T. G. C.,Arnould, J. C.,Bertrandie, A.,Jung, F. H.
, p. 2643 - 2651 (2007/10/02)
Two series of cephalosporins A and B have been synthesized, bearing at C-3' catechols substituted with various electron withdrawing groups (Y) and differing links (X), and were evaluated for their in vitro antibacterial activity and their pharmacokinetics
