108122-14-1

Basic information

• Product Name: (2-iodoethyl)(Methyl)sulfane
• Synonyms: (2-iodoethyl)(Methyl)sulfane;1-iodo-2-(methylthio)ethane
• CAS NO: 108122-14-1
• Molecular Formula: C₃H₇IS
• Molecular Weight: 202.05715
• EINECS: -0
• Mol File: 108122-14-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-iodoethyl)(Methyl)sulfane(CAS DataBase Reference)
• NIST Chemistry Reference: (2-iodoethyl)(Methyl)sulfane(108122-14-1)
• EPA Substance Registry System: (2-iodoethyl)(Methyl)sulfane(108122-14-1)

Safety Data

• Hazardous Substances Data: 108122-14-1(Hazardous Substances Data)

Usage

General Description

(2-iodoethyl)(Methyl)sulfane is a compound composed of one molecule of ethyl iodide and one molecule of methyl sulfane. Ethyl iodide, also known as iodoethane, is a colorless liquid with a strong, sweet odor. It is commonly used as a laboratory reagent in organic synthesis and as an alkylating agent. Methyl sulfane, or methanethiol, is a colorless gas with a strong, unpleasant odor. It is used as a precursor to certain organosulfur compounds and as a reagent in organic synthesis. The combination of these two compounds results in a potentially reactive and volatile chemical that should be handled with care and in accordance with proper safety protocols.

Upstream product

• 542-81-4 sulfure de methyle et de 2-chloroethyle 

Downstream Products

• 781650-34-8 tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-1-[2-(methylthio)ethyl]-2-oxoazepan-3-ylcarbamate 
• 21281-74-3 2-hydroxyethyl methyl sulfoxide 
• 5271-38-5 2-methylmercapto-ethanol 
• 134369-51-0 2-chloro-5-(methylthioethyl)pyrido[2,3-b][1,4]benzoxazepin-6(5H)one 
• 140413-45-2 2,4-dimethyl-6-methoxypyrido<2,3-b><1,4>benzoxazepine 
• 127628-13-1 dimethyl (2S,3aR,8aS)-2-(2-methylthioethyl)-8-(p-tolylsulphonyl)-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole-1,2-dicarboxylate 

Relevant articles and documents

O2-sulfonylethyl protected isopropylamine diazen-1-ium-1,2- diolates as nitroxyl (HNO) donors: Synthesis, β-elimination fragmentation, HNO release, positive inotropic properties, and blood pressure lowering studies

New types of nonexplosive O2-sulfonylethyl protected (-CH 2CH2SO2R; R = OMe, NHOMe, NHOBn, Me) derivatives of isopropylamine diazen-1-ium-1,2-diolate (IPA/NO) (2-5) were developed that are designed to act as novel HNO donors. These compounds, with suitable half-lives (6.6-17.1 h) at pH 7.4, undergo a base-induced β-elimination reaction that releases a methyl vinyl sulfone product and the parent IPA/NO anion which subsequently preferentially releases HNO (46-61% range). Importantly, the O2-methylsulfonylethyl compound 5 exhibited a significant in vitro inotropic effect up to 283% of the baseline value and increased the rates of contraction and relaxation but did not induce a chronotropic effect. Furthermore, compound 5 (22.5 mg/kg po dose) provided a significant reduction in blood pressure up to 6 h after drug administration. All these data suggest that O2-sulfonylethyl protected derivatives of IPA/NO, which are efficient HNO donors, could have potential applications to treat cardiovascular disease(s) such as congestive heart failure.