108122-32-3Relevant academic research and scientific papers
6-Alkoxy-N,N-disubstituted-2-pyridinamines as Anticonvulsant Agents
Pavia, Michael R.,Taylor, Charles P.,Hershenson, Fred M.,Lobbestael, Sandra J.
, p. 1210 - 1214 (2007/10/02)
The anticonvulsant effect of a series of 6-alkoxy-N,N-disubstituted-2-pyridinamines is described. An investigation was carried out to optimize the activity/side-effect ratio in this series of compounds. The most desirable profile was seen with 1-piperazine, 6, and this compound was selected for a more complete pharmacological evaluation. Overall, 6 has a pharmacological profile that is very similar to that of diphenylhydantoin (phenytoin). While nearly equipotent to phenytoin, animal studies suggest a fairly short duration of action. In addition, 6 exhibited some troublesome side effects including central nervous system depression and hypothermia.
