1081314-05-7

Basic information

• Product Name: C₁₁H₇BrF₃NS
• Synonyms: C₁₁H₇BrF₃NS
• CAS NO: 1081314-05-7
• Molecular Weight: 322.148
• Mol File: 1081314-05-7.mol

Chemical Properties

• CAS DataBase Reference: C₁₁H₇BrF₃NS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₇BrF₃NS(1081314-05-7)
• EPA Substance Registry System: C₁₁H₇BrF₃NS(1081314-05-7)

Safety Data

• Hazardous Substances Data: 1081314-05-7(Hazardous Substances Data)

Upstream product

• 300819-51-6 2-amino-5-(3-trifluoromethylbenzyl)-1,3-thiazole 

Downstream Products

• 1081314-07-9 C₂₇H₃₃F₃N₂O₄SSi 
• 1186325-50-7 C₂₀H₁₉F₃N₂OS 

Relevant articles and documents

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation

The continuing investigation of SAR studies of 3-(2-hydroxyethoxy)-N-(5-benzylthiazol-2-yl)-benzamides as stearoyl-CoA desaturase-1 (SCD-1) inhibitors is reported. Our prior hit-to-lead effort resulted in the identification of 1a as a potent and orally efficacious SCD-1 inhibitor. Further optimization of the structural motif resulted in the identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide (37c) with sub nano molar IC50 in both murine and human SCD-1 inhibitory assays. This compound demonstrated a dose-dependent decrease in the plasma desaturation index in C57BL/6J mice on a non-fat diet after 7 days of oral administration.