108134-40-3Relevant academic research and scientific papers
Synthesis of 4-Ylidenebutenolides. A Practical Route to 2-En-4-ynoic Acid Intermediates based on Conjugate Addition of Alkynyl-lithium Reagents
Clemo, Nicholas G.,Pattenden, Gerald
, p. 2133 - 2136 (2007/10/02)
Conjugate addition of alkynyl-lithium reagents to diethyl ethoxymethylenemalonate, followed by simultaneous saponification and 1,2-elimination of ethanol from the intermediate adducts, viz (18), in the presence of ethanolic potassium hydroxide, provides a useful synthesis of substituted propargylidenemalonic acids (19).Cyclisation of the propargylidenemalonic acids, using known procedures then leads to the corresponding 4-ylidenebutenolides, e.g. (20) and (21)
