108137-74-2Relevant academic research and scientific papers
Structural studies of 4-aminoantipyrine derivatives
Cunha, Silvio,Oliveira, Shana M.,Rodrigues Jr., Manoel T.,Bastos, Rodrigo M.,Ferrari, Jailton,De Oliveira, Cecília M.A.,Kato, Lucília,Napolitano, Hamilton B.,Vencato, Ivo,Lariucci, Carlito
, p. 32 - 39 (2005)
Reaction of 4-aminoantipyrine with acetylacetone, ethyl acetoacetate, benzoyl isothiocyanate, phenyl isothiocyanate, maleic anhydride and methoxymethylene Meldrum's acid afforded a series of new antipyrine derivatives. The antibacterial activity of the synthesized compounds against Micrococcus luteus ATCC 9341, Staphilococcus aureus ATCC 29737, and Escherichia coli ATCC 8739 was evaluated and the minimal inhibitory concentration determined. Modest activity was found only to the maleamic acid obtained from the reaction of 4-aminoantipyrine and maleic anhydride. 1H NMR investigation of this maleamic acid showed that it is slowly converted to the corresponding toxic maleimide. The structures of three derivatives were determined by X-ray diffraction analysis.
ETUDE COMPARATIVE DE LA REACTIVITE DE COMPOSES β-DICARBONYLES ET DES ANALOGUES ENAMINOCARBONYLES VIS-A-VIS D'AMINES HETEROCYCLIQUES
Maquestiau, A.,Eynde, J.-J. vanden
, p. 641 - 648 (2007/10/02)
Reactions between five β-dicarbonyl compounds (1-5) or their enaminocarbonyl analogues (6-10) and three heterocyclic amines (12-14) are studied.The two types of carbonyl derivatives give rise to the formation of the same final products.Kinetic data are es
