108138-54-1Relevant articles and documents
A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues
Verlee, Arno,Heugebaert, Thomas,Van Der Meer, Tom,Kerchev, Pavel I.,Van Breusegem, Frank,Stevens, Christian V.
, p. 303 - 312 (2017)
For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonyl)benzoyl chloride. Although a chemoselective process in batch was already reported, a continuous-flow process reveals an increased selectivity at higher temperatures and without catalysts. In total, 15 analogues were synthesized, using similar conditions, with yields ranging between 65 and 99%. This is the first automated and chemoselective synthesis of m-sulfamoylbenzamide analogues.
Chemoselective synthesis of aryl carboxamido sulfonic acid derivatives
Yang, Yung-Lin,Rajagopal, Basker,Liang, Chien-Fu,Chen, Chun-Chi,Lai, Hsiu-Ping,Chou, Chih-Hung,Lee, Yen-Pin,Yang, Yen-Ling,Zeng, Jing-Wen,Ou, Chun-Lin,Lin, Po-Chiao
, p. 2640 - 2646 (2013/03/28)
A one-pot two-step synthetic strategy for the preparation of aryl carboxamido sulfonic acid derivatives was developed. The synthesis started from m-(chlorosulfonyl)benzoyl chloride, which was reacted with amines, alcohols, thiols, or sodium azide and cata
