108162-01-2Relevant academic research and scientific papers
IMPROVED METHODS FOR THE REDUCTIVE ALKYLATION OF METHOXYBENZOIC ACIDS AND ESTERS: APPLICATION TO THE SYNTHESIS OF BICYCLIC KETONES
Hamilton, Robert J.,Mander, Lewis N.,Sethi, S. Paul
, p. 2881 - 2892 (2007/10/02)
A series of methoxybenzoic acids and esters was reduced by metal-ammonia solutions and the resulting 1,4-dihydro products were either alkylated subsequently.Three different types of alkyl iodies were employed to introduce the elements of a butanone or pentanone side-chain as a prelude to adding a fused six-membered ring, thereby completing the preparation of several analogues of the Wieland-Miescher ketone 4a in which the angular substituent was oxygenated.
