108176-66-5 Usage
General Description
1-(2H-1,4-benzothiazin-3-yl)-3-phenylurea is a chemical compound that belongs to the class of benzothiazinones. It is known for its potential as an inhibitor of the enzyme DprE1, which is involved in the cell wall biosynthesis of Mycobacterium tuberculosis, the bacterium that causes tuberculosis. 1-(2H-1,4-benzothiazin-3-yl)-3-phenylurea has shown promising antimycobacterial activity and has gained attention as a potential drug candidate for the treatment of tuberculosis. Additionally, it has been studied for its potential application in combination therapy for multidrug-resistant tuberculosis. Its chemical structure and properties make it a valuable tool for the development of new and more effective treatments for tuberculosis.
Check Digit Verification of cas no
The CAS Registry Mumber 108176-66-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,1,7 and 6 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 108176-66:
(8*1)+(7*0)+(6*8)+(5*1)+(4*7)+(3*6)+(2*6)+(1*6)=125
125 % 10 = 5
So 108176-66-5 is a valid CAS Registry Number.
108176-66-5Relevant articles and documents
Synthesis and Biological Activity of Some New N-(2H-1,4-benzoxazin- and benzothiazin-3-yl)-N'-arylureas
Shridhar, D. R.,Sastry, C. V. Reddy,Bansal, O. P.,Rao, P. Pulla
, p. 874 - 876 (2007/10/02)
A series of new N-(2H-1,4-benzoxazin- and benzothiazin-3-yl)-N'-arylureas (IV) and N-(4-methyl-2H-1,4-benzothiazinylidin-3-yl)-N'-arylureas (V) have been synthesised and screened for antiinflammatory, CNS, anthelmintic, antiprotozoal and antimicrobial activities.Some of the compounds possess a low order of antiinflammatory and mild CNS depressant activities.
