108190-71-2Relevant academic research and scientific papers
Modifications of Primaquine as Antimalarials. 4. 5-Alkoxy Derivatives of Primaquine
Chen, Eugene H.,Tanabe, Keiichi,Saggiomo, Andrew J.,Nodiff, Edward A.
, p. 1193 - 1199 (2007/10/02)
Thirty-two 5-alkoxyprimaquines have been synthesized and evaluated as blood schizonticides (Plasmodium berghei, mouse) and tissue schizonticides (Plasmodium cynomolgi, monkey). Several of these compounds were extremely active in both screens. Such a broad spectrum of antimalarial efficacy offers the possibility of a single drug that could cure the various relapsing and nonrelapsing malarias.
