108191-21-5

Basic information

• Product Name: Benzenemethanamine, N-[(4-aminophenyl)methyl]-a-methyl-
• CAS NO: 108191-21-5
• Molecular Formula: C15H18N2
• Molecular Weight: 226.321
• Mol File: 108191-21-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, N-[(4-aminophenyl)methyl]-a-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, N-[(4-aminophenyl)methyl]-a-methyl-(108191-21-5)
• EPA Substance Registry System: Benzenemethanamine, N-[(4-aminophenyl)methyl]-a-methyl-(108191-21-5)

Safety Data

• Hazardous Substances Data: 108191-21-5(Hazardous Substances Data)

Upstream product

• 85592-75-2 4-amino-N-(1-phenylethyl)benzamide 

Relevant articles and documents

Synthesis and Anticonvulsant Activity of Analogues of 4-Amino-N-(1-phenylethyl)benzamide

A group of amides and amines related to 4-amino-N-(1-phenylethyl)benzamide, 1, were prepared in a study on the relationship of structure to anticonvulsant activity in this compound. Acylation and alkylation of the amino group of 1 resulted in almost total loss of anticonvulsant activity. Insertion of a methylene between the 4-amino group and the aromatic ring of 1 produced a slight increase in anticonvulsant potency and a significant increase in toxicity. Hydride reduction of the amide carbonyl in 1 also yielded compounds having a slightly lower ED50 against convulsions induced by electroshock and a much lower TD50 in the rotorod assay. Modification of the 1-phenylethyl group of 1 also decreased anticonvulsant potency.