108200-18-6

Basic information

• Product Name: 1-BROMO-2-CHLOROBUTANE
• Synonyms: 1-BROMO-2-CHLOROBUTANE;2-CHLORO-1-BROMOBUTANE;1-BROMO-2-CHLOROBUTANE TECH
• CAS NO: 108200-18-6
• Molecular Formula: C₄H₈BrCl
• Molecular Weight: 171.46
• Mol File: 108200-18-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 142°C at 760 mmHg
• Flash Point: 51.3°C
• Appearance: /
• Density: 1.434g/cm³
• Vapor Pressure: 7.15mmHg at 25°C
• Refractive Index: 1.466
• CAS DataBase Reference: 1-BROMO-2-CHLOROBUTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2-CHLOROBUTANE(108200-18-6)
• EPA Substance Registry System: 1-BROMO-2-CHLOROBUTANE(108200-18-6)

Safety Data

• Hazardous Substances Data: 108200-18-6(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Molecular weight

163.46 g/mol

Uses

Intermediate in organic synthesis and pharmaceutical industry

Chemical classification

Halogenated alkane

Functional groups

Contains both bromine and chlorine atoms

Reactivity

Used as a reagent in chemical reactions such as nucleophilic substitution and organic synthesis

Hazardous properties

Can cause irritation to skin, eyes, and respiratory system

Safety precautions

Handle with caution, store in a well-ventilated area, and use appropriate personal protective equipment (PPE) when working with it.

InChI:InChI=1/C4H8BrCl/c1-2-4(6)3-5/h4H,2-3H2,1H3

Upstream product

• 109-65-9 1-bromo-butane 
• 106-98-9 1-butylene 

Relevant articles and documents

Practical and Selective sp3 C?H Bond Chlorination via Aminium Radicals

The introduction of chlorine atoms into organic molecules is fundamental to the manufacture of industrial chemicals, the elaboration of advanced synthetic intermediates and also the fine-tuning of physicochemical and biological properties of drugs, agrochemicals and polymers. We report here a general and practical photochemical strategy enabling the site-selective chlorination of sp3 C?H bonds. This process exploits the ability of protonated N-chloroamines to serve as aminium radical precursors and also radical chlorinating agents. Upon photochemical initiation, an efficient radical-chain propagation is established allowing the functionalization of a broad range of substrates due to the large number of compatible functionalities. The ability to synergistically maximize both polar and steric effects in the H-atom transfer transition state through appropriate selection of the aminium radical has provided the highest known selectivity in radical sp3 C?H chlorination.