1082059-14-0

Basic information

• Product Name: methyl 3-(4-((trimethylsilyl)ethynyl)phenyl)propanoate
• Synonyms: methyl 3-(4-((trimethylsilyl)ethynyl)phenyl)propanoate
• CAS NO: 1082059-14-0
• Molecular Weight: 260.408
• Mol File: 1082059-14-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 3-(4-((trimethylsilyl)ethynyl)phenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4-((trimethylsilyl)ethynyl)phenyl)propanoate(1082059-14-0)
• EPA Substance Registry System: methyl 3-(4-((trimethylsilyl)ethynyl)phenyl)propanoate(1082059-14-0)

Safety Data

• Hazardous Substances Data: 1082059-14-0(Hazardous Substances Data)

Upstream product

• 33994-44-4 3-(4-iodophenyl)propionic acid methyl ester 
• 1066-54-2 trimethylsilylacetylene 
• 1643-30-7 3-(4-bromophenyl)propionic acid 
• 75567-84-9 methyl 3-(4-bromopehynl)propanoate 

Downstream Products

• 1068471-18-0 methyl 3-(4-ethynylphenyl)propanoate 
• 1384529-23-0 C₁₇H₂₅O₄PSi 
• 1082059-12-8 methyl 3-(4-(phenylethynyl)phenyl)propanoate 
• 1082058-90-9 3-(4-(phenylethynyl)phenyl)propanoic acid 

Relevant articles and documents

SNP discrimination by tolane-modified peptide nucleic acids: Application for the detection of drug resistance in pathogens

During the treatment of viral or bacterial infections, it is important to evaluate any resistance to the therapeutic agents used. An amino acid substitution arising from a single base mutation in a particular gene often causes drug resistance in pathogens. Therefore, molecular tools that discriminate a single base mismatch in the target sequence are required for achieving therapeutic success. Here, we synthesized peptide nucleic acids (PNAs) derivatized with tolane via an amide linkage at the N-terminus and succeeded in improving the sequence specificity, even with a mismatched base pair located near the terminal region of the duplex. We assessed the sequence specificities of the tolane-PNAs for single-strand DNA and RNA by UV-melting temperature analysis, thermodynamic analysis, an in silico conformational search, and a gel mobility shift assay. As a result, all of the PNA-tolane derivatives stabilized duplex formation to the matched target sequence without inducing mismatch target binding. Among the different PNA-tolane derivatives, PNA that was modified with a naphthyl-type tolane could efficiently discriminate a mismatched base pair and be utilized for the detection of resistance to neuraminidase inhibitors of the influenza A/H1N1 virus. Therefore, our molecular tool can be used to discriminate single nucleotide polymorphisms that are related to drug resistance in pathogens.

COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES

There is provided novel compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type Il diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.