108237-02-1

Upstream product

• 121234-52-4 bis-(2-phenyl-4H-chromen-4-yl)-malononitrile 
• 109-77-3 malononitrile 
• 6272-41-9 2-phenylchromenylium perchlorate 
• 644-78-0 2-hydroxychalcone 

Relevant academic research and scientific papers

Selective synthesis of cyano-functionalized 2-aryl-4 h -chromenes and 2-amino-4 H -chromene-3-carbonitriles by catalyst-tuned reactions of 2-hydroxychalcones with 2-substituted acetonitriles

A selective synthesis of 4H-chromenes by the reactions of 2-hydroxychalcone derivatives with acetonitriles substituted with electron-withdrawing groups is described. Under catalyst-free conditions, the reactions give cyano-functionalized 2-aryl-4H-chromenes, whereas in the presence of sodium bicarbonate, 2-amino-4H-chromene-3-carbonitriles are obtained in excellent yields. Georg Thieme Verlag Stuttgart New York.