1082496-60-3

Basic information

• Product Name: 1-(3-isocyanatopropyl)-4-chlorobenzene
• Synonyms: 1-(3-isocyanatopropyl)-4-chlorobenzene
• CAS NO: 1082496-60-3
• Molecular Weight: 195.648
• Mol File: 1082496-60-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3-isocyanatopropyl)-4-chlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-isocyanatopropyl)-4-chlorobenzene(1082496-60-3)
• EPA Substance Registry System: 1-(3-isocyanatopropyl)-4-chlorobenzene(1082496-60-3)

Safety Data

• Hazardous Substances Data: 1082496-60-3(Hazardous Substances Data)

Upstream product

• 4619-18-5 4-(4-chlorophenyl)butanoic acid 
• 79-22-1 methyl chloroformate 

Downstream Products

• 1162018-16-7 C₂₆H₂₄ClN₃O₂S 

Relevant articles and documents

Design and synthesis of sulfonamidophenylethylureas as novel cardiac myosin activator

To optimize the lead urea scaffold 1 and 2 as selective cardiac myosin ATPase activator, a series of urea derivatives have been synthesized to explore its structure activity relationship. Among them N,N-dimethyl-4-(2-(3-(3-phenylpropyl)ureido)ethyl)benzenesulfonamide (13, CMA = 91.6%, FS = 17.62%; EF = 11.55%), N,N-dimethyl-4-(2-(1-methyl-3-(3-phenylpropyl)ureido)ethyl)benzene sulfonamide (40, CMA = 52.3%, FS = 38.96%; EF = 24.19%) and N,N-dimethyl-4-(2-(3-methyl-3-(3-phenylpropyl)ureido)ethyl)benzenesulfonamide (41, CMA = 47.6%, FS = 23.19%; EF = 15.47%) proved to be efficient to activate the cardiac myosin in vitro and in vivo. Further the % change in ventricular cell contractility at 5 μM of 13 (47.9 ± 3.2), 40 (45.5 ± 2.4) and 41 (63.5 ± 2.2) showed positive inotropic effect in isolated rat ventricular myocytes. The potent compounds 13, 40, 41 were highly selective for cardiac myosin over skeletal and smooth muscle myosin, thus proving them these new urea derivatives is a novel scaffold for discovery of cardiac myosin activators for the treatment of systolic heart failure.

Compounds with cardiac myosin activating function and pharmaceutical composition containing the same for treating or preventing heart failure

Disclosed are a compound having cardiotonic activity and a pharmaceutical composition containing the same, and the composition containing the compound, according to the present invention, is useful for preventing and treating heart failure.COPYRIGHT KIPO 2016