1082606-02-7Relevant articles and documents
Development of a second generation of inhibitors of microsomal prostaglandin E synthase 1 expression bearing the γ-hydroxybutenolide scaffold
Aquino, Maurizio,Guerrero, Maria D.,Bruno, Ines,Terencio, Maria C.,Paya, Miguel,Riccio, Raffaele
, p. 9056 - 9064 (2008/12/23)
Petrosaspongiolide M (PM, 1), a marine sesterterpene metabolite bearing the γ-hydroxybutenolide scaffold and displaying a potent inhibitory activity toward PLA2 enzyme, was selected by us as an attractive target in order to explore its mechanis