108273-71-8Relevant articles and documents
Zinc complex of tryptophan appended 1,4,7,10-tetraazacyclododecane as potential anticancer agent: Synthesis and evaluation
Adhikari, Anupriya,Kumari, Neelam,Adhikari, Manish,Kumar, Nitin,Tiwari, Anjani K.,Shukla, Abha,Mishra, Anil K.,Datta, Anupama
, p. 3483 - 3490 (2017)
With the rising incidences of cancer cases, the quest for new metal based anticancer drugs has led to extensive research in cancer biology. Zinc complexes of amino acid residue side chains are well recognized for hydrolysis of phosphodiester bond in DNA a
Evaluation of methionine and tryptophan derivatised vehicles: Met-ac-TE3A / Trp-ac-TE3A for tumor imaging
Singh, Sweta,Tiwari, Anjani K.,Varshney, Raunak,Mathur, Rashi,Hazari, Puja P.,Singh,Mishra, Anil K.
, p. 41977 - 41984 (2015)
Two novel amino acid (methionine and tryptophan) appended 1,4,8,11-tetraazacyclotetradecane triacetate (TE3A) compounds Met-ac-TE3A and Trp-ac-TE3A were synthesized and evaluated for imaging applications. The pharmacokinetics of these compounds was analyzed by 99mTc labeled tracer methods. In vitro human serum stability of 99mTc labeled Met-ac-TE3A/Trp-ac-TE3A was found to be 96.5% and 96.0% after 24 h respectively. Blood kinetics of both the labeled probes on normal rabbits showed biphasic clearance. The tumor (EAT cell line) grafted in balb/c mice were readily identifiable in the gamma images. Biodistribution revealed significant tumor uptake and good contrast in the EAT tumor bearing mice and also showed high tumor/muscles ratio which is a requisite condition to work as SPECT-radiopharmaceutical for tumor imaging. To look its future applicability for therapy using M+2 and M+3 metal ions, we performed thermodynamic stability constants of complexes derived from Met-ac-TE3A and Trp-ac-TE3A with CuII and LnIII metal ions.
Compound containing indole structure as well as preparation method and application thereof
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Paragraph 0057-0059, (2022/01/10)
According to the indole structure-containing compound and the preparation method thereof, the indole structure-containing compound has high biological activity on soil-borne pathogenic bacteria, fungi and nematodes, can be widely applied to prevention and treatment of soil-borne diseases, and provides material guarantee for safe production of crops.