108288-03-5Relevant academic research and scientific papers
Fungicidal pyridazines
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, (2008/06/13)
Plants are protected from the damaging effects of Phycomycetous fungi by a series of pyridazines of formula STR1 wherein R3 is chloro, bromo, methyl, cyano or iodo; R is chloro, bromo, iodo, methyl, cyano or furan-2-ylmethoxy; R1 is
Synthesis of 3,6-Dichloro-4-(2-chloro-1,1-dimethylethyl)pyridazine
Hackler, Ronald E.,Dreikorn, Barry A.,Johnson, George W.,Varie, David L.
, p. 5704 - 5709 (2007/10/02)
3,6-Dichloro-4-(2-chloro-1,1-dimethylethyl)pyridazine (3) is a systemic plant fungicide whose synthesis by several routes is described.Free-radical alkylations of 3,6-dichloropyridazine (1) gave either the 4-tert-butyl derivative 2 or the alcohol 3,6-dichloro-β,β-dimethyl-4-pyridazineethanol (24).Pyridazine (2) must be subjected to a free-radical chlorination, which resulted in other products, but alcohol 24 could be smoothly converted to 3.Alternatively, the pyridazine ring was constructed with the side chain preattached by utilizing lactone intermediates 10 or 18.The lactone 10 with hydrazine yielded the ether 11, and chlorination with ether cleavage proceeded to 3.Lactone 20 could not be transformed to 3.
